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Biology

Stage 6 · HSC questions by topic

About this subject

Biology

Atlas organises human-reviewed questions against the NSW Stage 6 Biologysyllabus. Every published question retains its exam source and page.

Syllabus: NESA Stage 6 (2017)
Explore the NESA Stage 6 (2017) syllabus topics

Module 5: Heredity

  • Reproduction
  • Cell Replication
  • DNA and Polypeptide Synthesis
  • Genetic Variation
  • Inheritance Patterns in a Population

Module 6: Genetic Change

  • Mutation
  • Biotechnology
  • Genetic Technologies

Module 7: Infectious Disease

  • Causes of Infectious Disease
  • Responses to Pathogens
  • Immunity
  • Prevention, Treatment and Control

Module 8: Non-infectious Disease and Disorders

  • Homeostasis
  • Causes and Effects
  • Epidemiology
  • Prevention
  • Technologies and Disorders
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259 questions found

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2026Practice
Q1

Identify two structural barriers that can reduce the entry of pathogens into an organism.

2 marks
Short answer
2026Practice
Q2

Explain how transmission pathways influence strategies used to control an infectious disease.

3 marks
Short answer
2026Practice
Q3 (a)

Describe the roles of two types of white blood cell during an immune response.

3 marks
Short answer
2026Practice
Q3 (b)

Explain why a secondary immune response is usually faster than a primary immune response.

4 marks
Short answer
2026Practice
Q4

Assess how a coordinated public health response can limit the impact of an emerging infectious disease.

6 marks
Extended response
2024HSC
Q1

Which of the following are non-cellular pathogens?
A. Bacteria
B. Fungi
C. Prions
D. Protozoa

1 mark
Multiple choice
2024HSC
Q2

Resin produced by spinifex grass has long been used by Aboriginal Peoples. Spinifex resin is currently used to produce medicinal creams. What is this an example of?
A. Biotechnology
B. Selective breeding
C. Artificial insemination
D. Genetically modified organisms

1 mark
Multiple choice
2024HSC
Q3

The image shows a chromosome that has undergone mutation. Each letter represents a gene.
What type of mutation has occurred?
A. Deletion
B. Duplication
C. Inversion
D. Substitution

1 mark
Multiple choice
2024HSC
Q4

Which row of the table correctly identifies components of DNA?

1 mark
Multiple choice
2024HSC
Q5

The diagram shows a cell reproducing.
Which row of the table correctly identifies the method of reproduction and the type of organism shown in the diagram?

Method of reproductionType of organism
A.BuddingFungi
B.Binary fissionBacteria
C.Production of sporesPlant
D.Gamete productionProtist
1 mark
Multiple choice
2024HSC
Q7

How do stomata maintain water balance in plants?
A. They close in hot weather to decrease transpiration.
B. They open in cold weather to decrease transpiration.
C. They open in hot weather to decrease evaporative cooling.
D. They close in cold weather to decrease evaporative cooling.

1 mark
Multiple choice
2024HSC
Q8

Trypanosomes (Trypanosoma brucei) are protozoans that cause African sleeping sickness in humans. The diagram shows the way that the disease is transmitted to humans.
Which row of the table identifies the pathogen, vector and method of disease transmission to humans?

PathogenVectorMethod of disease transmission
A.TrypanosomesTsetse flyDirect
B.Tsetse flyCowDirect
C.TrypanosomesTsetse flyIndirect
D.Tsetse flyCowIndirect
1 mark
Multiple choice
2024HSC
Q9

The diagram shows a section of a chromosome in an insect. It represents three genes amongst non-coding DNA. The crosses mark locations of four separate mutations.
Which location could produce a new allele for eye colour?
A. P
B. Q
C. R
D. S

1 mark
Multiple choice
2024HSC
Q10

Francesco Redi challenged the idea that maggots arose spontaneously from rotting meat. A modern version of his experiment was set up as shown.
Which of the following is correct for this experimental set up?
A. The sealed jar improves the validity of the experiment.
B. The independent variable is whether the meat spoils or not.
C. The use of three jars improves the reliability of the experiment.
D. The dependent variable is the use of different covers for the jars.

1 mark
Multiple choice
2024HSC
Q11

The data shows the proportion of adults living in Australia who are obese.
Which of the following can be observed from the data?
A. The proportion of obese adults always increases with age.
B. There is a greater percentage of men who are obese than women in all age groups.
C. The proportion of women who are obese increases from 13% at 18–24 to 38% at 65–74.
D. The proportion of men who are obese increases from 18% at 18–24 to 35% at 45–54, then decreases to 23% at age 85 and over.

1 mark
Multiple choice
2024HSC
Q12

Robert Koch produced a set of criteria to establish whether a particular organism is the cause of a disease in an animal. The criteria are listed below but not in the correct order.

  1. The microorganism must cause disease when introduced to a healthy experimental animal.
  2. The microorganism must be extracted and isolated from the diseased animal and subsequently grown in culture.
  3. The microorganism must be extracted from the diseased experimental animal and demonstrated to be the same microorganism that was isolated from the first diseased animal.
  4. The microorganism must be found in the diseased animal, and not found in healthy animals.
    Which of the following correctly shows the order of steps required to determine the cause of a particular disease in an animal?
    A. 2, 3, 1, 4
    B. 2, 4, 1, 3
    C. 4, 2, 1, 3
    D. 4, 3, 2, 1
1 mark
Multiple choice
2024HSC
Q13

Which of the following identifies plant responses to pathogens?
A. Increased phagocytosis and programmed cell death
B. Increased number of stomata and programmed cell death
C. Production of antihistamines and increased thickness of cell walls
D. Production of antimicrobial substances and increased thickness of cell walls

1 mark
Multiple choice
2024HSC
Q14

The graph shows the quantity of DNA in one mammalian cell over time.
Which of the statements about the cell’s activity is correct?
A. The cell is dividing during section O.
B. The cell is inactive for the first two hours.
C. The cell takes one hour to replicate its DNA.
D. The cell becomes diploid only during section N.

1 mark
Multiple choice
2024HSC
Q15

The graph shows the number of cases of Swine Flu (a viral respiratory illness) from May to July 2009 in Australia.
What effective control measures could have been introduced between May and July to limit the spread of the disease in Australia?

May–JuneJuly
A.Quarantine all people arriving in AustraliaEncourage people to wear masks and wash hands regularly
B.Issue antibiotics to overseas visitorsIsolate people with symptoms
C.Encourage people to wear masks and wash hands regularlyQuarantine all people arriving in Australia
D.Isolate people with symptomsVaccinate all people arriving in Australia
1 mark
Multiple choice
2024HSC
Q17

Over 12 months, the prevalence of a non-infectious disease will increase in a population if
A. the total population increases.
B. disease recovery time decreases.
C. the incidence rate of the disease decreases.
D. the survival time of individuals with the disease increases.

1 mark
Multiple choice
2024HSC
Q20

Analyse the following four pedigrees.
KEY Unaffected female Unaffected male 1 2 Affected female Affected male 3 4 © Epomedicine.com
Which row in the table correctly identifies the pedigree with the type of inheritance?

Autosomal dominantSex-linked dominantAutosomal recessiveSex-linked recessive
A.2134
B.1423
C.1324
D.2413
1 mark
Multiple choice
2024HSC
Q21 (a)

A diagram of the different parts of a flower is shown.

Identify the structures where pollen and ovules are located.
Pollen ................................................
Ovules ...............................................

2 marks
Short answer
2024HSC
Q22 (b)

A student designed and conducted a practical investigation to test for the presence of microbes in water and food samples.
Explain how the student could ensure the reliability of the investigation.

2 marks
Short answer
2024HSC
Q22 (a)

A student designed and conducted a practical investigation to test for the presence of microbes in water and food samples.
Justify a safety precaution required to prevent infection when conducting the investigation.

2 marks
Short answer
2024HSC
Q23

Outline how ONE type of electromagnetic radiation can cause a germline mutation.
Name of electromagnetic radiation: .................................

2 marks
Short answer
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